Impact of Alternative Routes and Timing of Dopamine and Mannitol Administrations to Reduce Negative Properties of Extended Cardiopulmonary Bypass on Renal Function in Coronary Artery Operations

Ejaz, Iqra and Naeem, Salwa and Munir, Mian Seher and Usman, Muhammad and Zafar, Sohail and Hanif, Faiza (2021) Impact of Alternative Routes and Timing of Dopamine and Mannitol Administrations to Reduce Negative Properties of Extended Cardiopulmonary Bypass on Renal Function in Coronary Artery Operations. Journal of Pharmaceutical Research International, 33 (54A). pp. 307-312. ISSN 2456-9119

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Abstract

Objectives: To analyze impact of alternative routes and timing of dopamine and mannitol administrations to reduce negative properties of extended cardiopulmonary bypass on renal function in coronary artery operations.

Methods: Set I (n: 26 individual): Mannitol (1 g/kg) has been introduced to the CPB priming solution. Set II (n: 25 patients): Even during interval among anesthetic induction and operation, 3 g/kg/min of IV dopamine was delivered. Group III (n = 25 patients): 2 g/kg/min IV dopamine was provided among anesthesia initiation and operation conclusion, and 1 g/kg mannitol were added to priming solution for CPB. Furosemide was administered to Group IV (n = 26 cases) when urine production was poor.

Results: There would be a substantial rise in the post-operative urine microalbumin/creatinine ratios over all classes (p 0.06), as well as a rise in cystatin-c in Set 1, 2, and 3 (p 0.02).

Conclusions: Researchers suggest that combining dopamine infusion (1 g/kg/min) and mannitol (2 g/kg) throughout CPB seems to be the more actual method for preventing detrimental possessions of CPB on renal functioning.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 16 Feb 2023 11:26
Last Modified: 05 Jul 2024 07:04
URI: http://research.asianarticleeprint.com/id/eprint/44

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