Rack1 Controls Parallel Fiber–Purkinje Cell Synaptogenesis and Synaptic Transmission

Yang, Haihong and Yang, Chaojuan and Zhu, Qian and Wei, Mengping and Li, Ying and Cheng, Juanxian and Liu, Fengjiao and Wu, Yan and Zhang, Jiyan and Zhang, Chen and Wu, Haitao (2019) Rack1 Controls Parallel Fiber–Purkinje Cell Synaptogenesis and Synaptic Transmission. Frontiers in Cellular Neuroscience, 13. ISSN 1662-5102

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Abstract

Purkinje cells (PCs) in the cerebellum receive two excitatory afferents including granule cells-derived parallel fiber (PF) and the climbing fiber. Scaffolding protein Rack1 is highly expressed in the cerebellar PCs. Here, we found delayed formation of specific cerebellar vermis lobule and impaired motor coordination in PC-specific Rack1 conditional knockout mice. Our studies further revealed that Rack1 is essential for PF–PC synapse formation. In addition, Rack1 plays a critical role in regulating synaptic plasticity and long-term depression (LTD) induction of PF–PC synapses without changing the expression of postsynaptic proteins. Together, we have discovered Rack1 as the crucial molecule that controls PF–PC synaptogenesis and synaptic plasticity. Our studies provide a novel molecular insight into the mechanisms underlying the neural development and neuroplasticity in the cerebellum.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 24 May 2023 07:15
Last Modified: 06 Jul 2024 08:03
URI: http://research.asianarticleeprint.com/id/eprint/933

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