hsCRP and ET-1 expressions in patients with no-reflow phenomenon after percutaneous coronary intervention

Liu, Min and Liang, Tian and Zhang, Peiying and Zhang, Qing and Lu, Lei and Wang, Zhongliang (2017) hsCRP and ET-1 expressions in patients with no-reflow phenomenon after percutaneous coronary intervention. Pakistan Journal of Medical Sciences, 33 (4). ISSN 1681-715X

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Abstract

Objective: To explore hsCRP and ET-1 expressions in patients with no-reflow phenomenon after percutaneous coronary intervention (PCI).

Methods: A total of 136 patients with single coronary artery disease receiving PCI were divided into a reflow group and a no-reflow group to compare the level use of ET-1 alone with combined level of ET-1 and hs-CRP in PCI regarding sensitivity, specificity, positive and negative predictive values and accuracy for postoperative no-reflow. The study was conducted between 2014-2016 at our hospital.

Results: Postoperative levels of ET-1 and hs-CRP in no-reflow group were significantly higher than those of reflow group (P<0.05). ET-1 level of reflow group peaked three hours after PCI and then declined. Serum level of hs-CRP decreased most obviously within three hours after PCI in reflow group and three hours - three days after PCI in no-reflow group. Left ventricular end-diastolic diameters of both groups after PCI were apparently lower than those before PCI, without significant inter-group difference (P>0.05). Left ventricular end-systolic diameters and left ventricular ejection fractions of both groups evidently increased after PCI, without significant inter-group differences either (P>0.05). Corrected TIMI frame count (CTFC) and wall motion score index of reflow group after PCI were significantly lower than those of no-reflow group (P<0.05). ET-1 level was positively correlated with CTFC (P<0.05). Multivariate linear regression showed hs-CRP was negatively correlated with the serum level (P<0.05) (r=-0.34).

Conclusion: hsCRP and ET-1 levels significantly increased in patients with no-reflow phenomenon.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 26 Apr 2023 07:14
Last Modified: 14 Sep 2024 04:42
URI: http://research.asianarticleeprint.com/id/eprint/692

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