Chronic paroxysmal hemicrania responsive to lamotrigine

This report details a 45-year-old woman who has been suffering right-sided temporal and orbital headache attacks during last five years. The pain is characteristically associated with ipsilateral lacrimation, ptosis and rhinorrhoea. The frequency and duration of pain increased dramatically within last two years. Detailed neurological, physical and clinical examinations as well as routine blood tests revealed no abnormality. Magnetic resonance imaging of brain was normal. The patient was clinically diagnosed as chronic paroxysmal hemicrania and initially treated with indomethacin. Due to appearance of epigastric pains indomethacin treatment was replaced with lamotrigine which successfully resolved the symptoms.