Endotelioand cardioprotective effects of HMG-Co-A reductase in endotoksininducing endotelial dysfunction

Denisuk, T. A. and Pokrovskii, M. V. and Philippova, O. V. and Gudyrev, O. S. and Pokrovskaya, T. G. and Korokin, M. V. and Osipova, O. A. (2015) Endotelioand cardioprotective effects of HMG-Co-A reductase in endotoksininducing endotelial dysfunction. Kuban Scientific Medical Bulletin, 5. pp. 51-55.

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Abstract

The use of inhibitors of HMG-Co-A reductase inhibitor simvastatin, atorvastatin, rosuvastatin and nanoparticulative rosuvastatin on background modeling endotoksininducing pathology, introduction of strain 603 Staphylococcusaureus leads to the development of dose-response endotelioprotectiv action, expressed in the normalization of QED, prevent increase adrenoreactivity and exhaustion of myocardial reserve and and normalization of biochemical markers of inflammation (C-reactive protein) and the level of proinflammatory cytokines. When this is detected positive dynamics and-products of NO and expression of eNOS.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 08 Apr 2023 08:12
Last Modified: 02 Oct 2024 07:24
URI: http://research.asianarticleeprint.com/id/eprint/516

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