Response of Wistar Rats to Low Doses of Bisphenol A

Bisphenol A is an industrial chemical widely used in the manufacture of polycarbonates (PCs), epoxy resins, and other polymeric materials. In this study the toxicity of different doses of oral bisphenol A to wistar rats was investigated. bisphenol A was given to rats at 2.5, 5, 10 and 20 µg/kg body weight /day for 12 weeks. All the treated rats had a significantly increased body weight, but none of the rats died during the 6 and 12 weeks’ period. Haematological and biochemical parameters were measured after six and twelve weeks of the experimental period. Behavioral changes and dosing resistance were observed in all the tested groups. After 12 weeks, different types of anemia (microcytic hypochromic, microcytic normochromic and normocytic normochromic) were observed in the different treated groups. The toxicity on the liver, toxicity on kidney and spleen was correlated with changes in the concentrations of AST (aspartate aminotransferase), ALT (alanine aminotransferase) and ALP (alkaline phosphatase) and the concentrations of globulins, glucose, cholesterol and urea. The toxic effect of bisphenol A was evident on the Haematological and Serobiochemical parameters.