Genetic Variability of TCF4 in Schizophrenia of Southern Chinese Han Population: A Case-Control Study

Yin, Jingwen and Zhu, Dongjian and Li, You and Lv, Dong and Yu, Huajun and Liang, Chunmei and Luo, Xudong and Xu, Xusan and Fu, Jiawu and Yan, Haifeng and Dai, Zhun and Zhou, Xia and Wen, Xia and Xiong, Susu and Lin, Zhixiong and Lin, Juda and Zhao, Bin and Wang, Yajun and Li, Keshen and Ma, Guoda (2019) Genetic Variability of TCF4 in Schizophrenia of Southern Chinese Han Population: A Case-Control Study. Frontiers in Genetics, 10. ISSN 1664-8021

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Abstract

Objective: Schizophrenia is thought to be a neurodevelopmental disorder. As a key regulator in the development of the central nervous system, transcription factor 4 (TCF4) has been shown to be involved in the pathogenesis of schizophrenia. The aim of our study was to assay the association of TCF4 single nucleotide polymorphisms (SNPs) with schizophrenia and the effect of these SNPs on phenotypic variability in schizophrenia in Southern Chinese Han Population.

Methods: Four SNPs (rs9960767, rs2958182, rs4309482, and rs12966547) of TCF4 were genotyped in 1137 schizophrenic patients and 1035 controls in a Southern Chinese Han population using the improved multiplex ligation detection reaction (iMLDR) technique. For patients with schizophrenia, the severity of symptom phenotypes was analyzed by the five-factor model of the Positive and Negative Symptom Scale (PANSS). Cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS) scale.

Results: The results showed that the genotypes and alleles of the three SNPs (rs2958182, rs4309482, and rs12966547) were not significantly different between the control group and the case group (all P > 0.05). rs9960767 could not be included in the statistics for the extremely low minor allele frequency. However, the genotypes of rs4309482 shown a potential risk in the positive symptoms (P = 0.04) and excitement symptoms (P = 0.04) of the five-factor model of PANSS, but not survived in multiple test correction. The same potential risk was shown in the rs12966547 in positive symptoms of the PANSS (P = 0.03).

Conclusion: Our results failed to find the associations of SNPs (rs2958182, rs4309482, and rs12966547) in TCF4 with schizophrenia in Southern Chinese Han Population.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 16 Feb 2023 11:27
Last Modified: 01 Aug 2024 10:27
URI: http://research.asianarticleeprint.com/id/eprint/197

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