Comparative Analysis of Adverse Drug Reactions of Agent Used in Gastroenterology in Patients with Comorbidities

This study compares adverse drug reactions (ADRs) associated with anti-gastroenterology agents in patients with comorbidities. The research evaluates various classes of medications, including proton pump inhibitors (PPIs), H2-receptor antagonists, 5-aminosalicylates, biologics, corticosteroids, immunosuppressants, prokinetics, and antacids. It highlights the frequency and severity of ADRs, Especially in patients with renal impairment, liver disease, osteoporosis, immunocompromised states, diabetes and cardiovascular diseases. The common adverse reactions of anti-gastroenterology agents were osteoporosis, hepatotoxicity and followed by renal impairment. The findings emphasize the need to carefully manage these agents to minimize risks and improve patient outcomes.