Anti Diabetic activity of Terminalia superba (Combretaceae) Stem Bark Extract in Streptozotocin Induced Diabetic Rats

Désiré, Dzeufiet Djomeni Paul and Benoît, Nguelefack Télesphore and Jacqueline, Azay and Gérard, Cros and Pierre, Kamtchouing and Théophile, Dimo (2014) Anti Diabetic activity of Terminalia superba (Combretaceae) Stem Bark Extract in Streptozotocin Induced Diabetic Rats. British Journal of Pharmaceutical Research, 4 (11). pp. 1300-1310. ISSN 22312919

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Abstract

Aims: The present study was designed to evaluate the antidiabetic activity of the methanol stem bark extract of Terminalia superb (T. superba), a traditionally used medicinal plant in Cameroon.
Place and Duration of Study: Departement of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon and Laboratoire de Pharmacologie et Physiopathologie Expérimentales, Université Montpellier I, France. Between Ferbruary 2011 and September 2011.
Methodology: In one set of experiments, repeated doses of T. superba extract (37.5– 300mg/kg, p.o.) were administrated once daily for 21 days to groups of diabetic rats. In another set of experiments, acute effect of the plant extract (37.5–300mg/kg) in diabetic rats was evaluated.
Results: Following acute treatment, the plant extract produced a significant reduction in the blood glucose levels in diabetic rats. T. superba (75–300mg/kg) significantly decreased the blood glucose levels in glucose loaded rats. Oral administration of T. superba extract for 21 days resulted in a 31.43% and 21.42% significant reduction in blood glucose levels at the dose of 75mg/kg and 300mg/kg respectively. The plant extract significantly, reduced the plasma urea levels (20%) and induced a significant elevation in plasma insulin in treated rats. The extract did not significantly change elevated plasma cholesterol and triglycerides resulting from diabetic conditions.
Conclusion: The antidiabetic effect of the methanol stem bark extract of T. superba seems to be a result of increase in glucose utilization due to stimulatory action on insulin release.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 13 Jul 2023 04:37
Last Modified: 21 Sep 2024 04:51
URI: http://research.asianarticleeprint.com/id/eprint/1193

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