Menghini, Luigi and Ferrante, Claudio and Leporini, Lidia and Pintore, Giorgio and Chiavaroli, Annalisa and Shohreh, Rugia and Recinella, Lucia and Orlando, Giustino and Vacca, Michele and Brunetti, Luigi (2013) A Natural Formulation Increases Brain Resistance to Oxidative Stress. European Journal of Medicinal Plants, 4 (2). pp. 171-182. ISSN 22310894
Menghini422013EJMP7150.pdf - Published Version
Download (313kB)
Abstract
Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initiating disruptive peroxidation reactions on cellular substrates such as proteins, lipids, and nucleic acids. Neurons have a high content of unsaturated fatty acids which are easily peroxidable by the elevated levels of ROS and RNS produced by brain oxygen metabolism, yielding isoprostanes among which 8-iso-PGF2α derived from arachidonic acid represents a stable marker of lipoperoxidation, in vivo. Numerous findings pointed to the protective role of natural products against oxidative stress in the brain.
Methodology: In the present work we evaluated the effects of a natural formula containing bacopa extract, vitamin E, astaxanthin and phosphatidylserine on lipoperoxidation in rat brain cortex, both in vivo and in vitro.
Results: The results demonstrate that the natural formula could reduce basal and hydrogen peroxide- and amyloid β peptide-induced oxidative stress, as evidenced by the reduction of 8-iso-PFG2α and ROS/RNS production in the rat brain.
Conclusion: Results could account for a rational use of herbal products in the treatment of conditions characterized by increased burden of oxidative stress and defective antioxidant mechanisms, such as aging and neurodegenerative disorders.
Item Type: | Article |
---|---|
Subjects: | STM Digital > Medical Science |
Depositing User: | Unnamed user with email support@stmdigital.org |
Date Deposited: | 06 Jul 2023 04:40 |
Last Modified: | 23 May 2024 07:43 |
URI: | http://research.asianarticleeprint.com/id/eprint/1136 |