The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies

Panegyres, Peter K. and Atkins, Emily R. (2011) The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies. Neuroscience and Medicine, 02 (04). pp. 397-409. ISSN 2158-2912

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Abstract

Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.

Item Type: Article
Subjects: STM Digital > Medical Science
Depositing User: Unnamed user with email support@stmdigital.org
Date Deposited: 27 Jan 2023 08:01
Last Modified: 15 Jun 2024 12:28
URI: http://research.asianarticleeprint.com/id/eprint/101

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